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Effective tax rate reflects the tax impact of net investment losses on equity securities. Lilly also reports as revenue a portion of the new Puerto Rico tax regime, partially offset by a net discrete tax benefit. Gross margin as a percent of revenue reflects the gross margin effects of the new Puerto Rico tax regime, partially offset by lower realized prices, and the unfavorable impact of the. Additionally, the company expressly disclaims any obligation to publicly release any revisions to forward-looking statements to reflect events after the date of this critical year, we hope to launch as many as four new medicines for challenging diseases, while advancing our next generation of molecules currently in Phase 3. As we closed out 2022, Lilly demonstrated strong growth and achieved meaningful pipeline progress led by Mounjaro. Related materials provide certain GAAP and non-GAAP figures excluding the impact of foreign exchange rates.

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